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Ossium Health

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Ossium Health

Ossium Health is a bioengineering company that leverages its proprietary organ donor bone marrow banking platform to develop stem cell therapies for patients with life-threatening blood and immune diseases. Founded in 2016, the company is led by Kevin Caldwell, CEO, Co-Founder & President, and Erik Woods, Chief Science Officer, Co-Founder & EVP. Ossium Health’s manufacturing facility is registered with the FDA and its laboratory is certified under the Clinical Laboratory Improvement Amendment (CLIA).

ossiumhealth.com
HQ: San Francisco, California, United States
200
Biotechnology & Agriculture

Company research

Public company, workplace, funding, and market signals

Updated Aug 16, 2026

Overview

Ossium Health is a privately held bioengineering and biotechnology company developing an organ-donor-derived bone-marrow banking platform. It recovers bone marrow from deceased organ donors, cryopreserves it, and makes hematopoietic stem-cell grafts available on demand for transplantation and other cell-therapy applications.

Primary product

An off-the-shelf, cryopreserved bone-marrow-derived hematopoietic stem-cell product, supported by the PRESERVE I clinical program; the company also offers OssiGraft and OssiGraft Prime viable bone-matrix allografts for orthopedic and spine procedures.

Founded

2016

Headquarters

80 Tehama Street, San Francisco, California 94105, United States

Team size

70-80

Industry

Biotechnology Research

Sub-industry

Cell therapy, hematopoietic stem-cell transplantation, tissue banking, cryopreservation, and regenerative medicine

Offices

San Francisco, California, United States
Indianapolis, Indiana, United States

Business model

Clinical-stage biotechnology product development
Commercial sale and distribution of viable bone-matrix allografts
Potential future supply of off-the-shelf cellular therapies to transplant centers
Government and research contracts

Funding

Stage

Series C / clinical-stage biotechnology company

Total raised

$128.9M

Latest round

Series C · Jul 2023

Latest amount

$52M

Series C

Jul 2023 · CPMG

$52M

Series B

Mar 2021 · Vivo Capital and General Catalyst

$63M

Venture Round

Jun 2020

Series A

May 2018

$10.4M

Grant

California Institute for Regenerative Medicine

People & investors

Leadership

Kevin Caldwell

Chief Executive Officer, President, and Co-Founder

Erik Woods

Executive Vice President, Chief Science Officer, and Co-Founder

Susannah Cantrell

Chief Commercial Officer

Brian Johnstone

Vice President, Research

Behdad Pournader

Director of Technology

Jane Griffin

Director, Regulatory Affairs

Chip Walker-Wilson

Senior Vice President and General Counsel

Preethi Prasad

Senior Director, Clinical Operations

Founders

Sebastian Eriksson Giwa

Historical founder, former CEO, and former executive chairman; current role at Ossium is not confirmed

Investors

Alumni Ventures
Asahi Kasei
California Institute for Regenerative Medicine
CPMG
First Round Capital
General Catalyst
Manta Ray Ventures
Vivo Capital

Work & culture

Ossium describes itself as mission-driven, results-oriented, data-led, ownership-minded, and resilient. Its work combines regulated manufacturing, clinical research, and biotechnology product development. The company has emphasized its impact on patients, donor families, clinical partners, and the broader transplant ecosystem.

Compensation

Publicly surfaced estimates include approximately $54,199 annually for Cell Therapy Associate II, $76,214 for Quality Engineer, and $100,763 for Quality Manager. These are third-party estimates rather than confirmed company salary bands; public evidence of visa sponsorship is unavailable.

Benefits

Public job and employer data indicate compensation and benefits are offered, but Ossium does not appear to publish a complete benefits summary publicly.
Roles span scientific, manufacturing, quality, clinical, commercial, and technology functions.
The company emphasizes mission-driven work, impact, ownership, truth, and grit.
Public employer-rating data cited by Exa indicates an overall rating of approximately 3.4/5 from 49 reviews.

Product & market

Pricing

Not publicly disclosed. The company appears to use institutional, clinical, commercial-product, distribution, and government-contract arrangements rather than consumer subscription pricing.

Differentiators

  • —Uses deceased organ donors as a new source of bone marrow rather than relying exclusively on living donors.
  • —Cryopreserves marrow for on-demand shipment, potentially reducing donor-search and scheduling delays.
  • —Vertically integrates donor recovery partnerships, marrow extraction, cryopreservation, manufacturing, quality systems, and clinical programs.
  • —Targets patients who cannot find a suitable living donor or require an urgent transplant.
  • —Its platform may support future hematopoietic, immune, organ-transplant, oncology, and musculoskeletal applications.
  • —Manufacturing facility is FDA-registered and laboratory operations are CLIA-certified.

Technology

Cryopreservation in liquid-nitrogen vapor storage
Bone-marrow recovery from vertebral bodies of deceased organ donors
Hematopoietic stem-cell processing and manufacturing
Cell therapy manufacturing
ISO 7 cleanrooms
Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory operations
FDA-registered manufacturing facility
Python
Django
Flask
PostgreSQL
MySQL
Docker
Jenkins
GitHub Actions
Terraform
Jira
MasterControl
NetSuite
MATLAB

Customers

Transplant centers and hospitals participating in Ossium clinical programs
Henry Ford Health
National Marrow Donor Program (NMDP) / Be The Match, as a clinical-program partner
Orthopedic and spine surgeons
Enovis, which distributes OssiGraft and OssiGraft Prime
Biomedical Advanced Research and Development Authority (BARDA), under a government contract

Competitors

Garuda Therapeutics
Be The Match BioTherapies / NMDP
HemaCare, a Charles River company
LeukoLab
Biovault Technical
Gift of Life Marrow Registry
Traditional living-donor marrow registries and cord-blood banks
Other allogeneic and off-the-shelf cell-therapy developers

Scale & contact

Estimated revenue

Approximately $1M-$10M annually; one third-party estimate is $1.2M

Estimated monthly visits

4.5K

Traffic estimate as of Jun 2026

Signals & risks

Other
Sep 2024

Ossium announced a BARDA contract initially funded at $21 million, with potential value up to $125 million over five years. The contract supports national preparedness but includes option-dependent potential value rather than guaranteed revenue.

Source
Other
Nov 2024

Independent reporting identified important clinical and scaling uncertainties, including possible effects of freezing on cell quality, potential relapse risk, the need for a large and diverse donor pool, and the requirement to demonstrate clinical effectiveness at scale.

Source
Other
Jan 2026

Commentary on the early PRESERVE I data noted that the clinical sample remains very small and that longer-term relapse, graft-versus-host disease, durability, product consistency, reimbursement, and regulatory classification remain unresolved questions.

Source

Latest news

Ossium Health to Present New Clinical Data on Its Organ Donor Bone Marrow at ASH 2025

Business Wire · Dec 2025

Ossium reported early data from four patients with hematologic malignancies treated with deceased-organ-donor-derived marrow; all four achieved reported neutrophil engraftment, platelet recovery, and full donor chimerism, with no chronic graft-versus-host disease reported by the company.

Susannah Cantrell Joins Ossium Health as Chief Commercial Officer

Ossium Health · Nov 2025

Ossium appointed Susannah Cantrell as chief commercial officer to lead commercial strategy, go-to-market planning, partnerships, and preparation for broader transplant-center availability.

Bone Marrow Donors Can Be Hard to Find. One Company Is Turning to Cadavers

WIRED · Nov 2024

WIRED described Ossium’s deceased-donor marrow-recovery and cryopreservation approach, its early clinical use, partnerships with organ-procurement organizations, and open questions around scale, cell quality, donor diversity, and clinical validation.

Ossium Health Secures BARDA Contract to Advance Bone Marrow Bank for Radiological and Nuclear Emergencies

Ossium Health · Sep 2024

Ossium announced a BARDA contract initially funded at $21 million, with potential total value of up to $125 million including options over five years.

Ossium Health Reports Positive Initial Outcomes for First Ever Leukemia Patient Treated with Organ Donor Derived Bone Marrow

Ossium Health · Sep 2024

The company reported its first leukemia patient treated with its product achieved neutrophil engraftment by day 16 and platelet engraftment by day 21, with no product-related adverse events reported at that time.

Careers / join the teamClinical program: PRESERVE ILinkedIn company pageNewsroomOfficial websiteSEC filingsSeries C announcementTeam/about page
SourcesOssium Health official websiteOssium Health company/about pageOssium Health newsroomSEC Form D filing for Ossium HealthExa company profile and estimates

Jobs and careers at Ossium Health

4 jobs at Ossium Health

Clinical Production Operator I/II, HPC Marrow

On-site
Clinical Production
Indianapolis, IN; Indianapolis, Indiana, United States
2w ago
On-site
Full-time
Apply

Medical Science Liaison (Western US)

Remote
Medical Affairs
Field Based: West; Remote - US
1mo ago
Remote
Full-time
Apply

Tissue Recovery Specialist (Contract) - Northern OR Southern Indiana

Remote
Donor Team
Field Based: Northern Indiana; Field Based: Southern Indiana; Remote - Indiana; Remote - US
2mo ago
Remote
Full-time
Apply

Chief Financial Officer

On-site
Finance
San Francisco, California, United States
2mo ago
On-site
Full-time
Apply

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