Endpoints News · Nov 2025
Described JAM-2 as a major step up in drug-like de novo antibody design, with better success rates, developability, and GPCR results.
We use AI to design antibodies for intractable diseases
Public company, workplace, funding, and market signals
Updated Jul 30, 2026
Nabla Bio is a Cambridge-based biotechnology company (founded in 2020, publicly launched in 2021) building JAM / JAM-2, a multimodal generative protein-design platform that combines AI with integrated wet-lab experimentation to design de novo antibodies and multispecific biologics for hard-to-drug targets, especially membrane proteins.
Primary product
JAM / JAM-2, a multimodal generative antibody design platform for de novo biologics design
Founded
2020
Headquarters
840 Memorial Dr, Riverside Technology Center, Cambridge, Massachusetts 02139, United States
Team size
11-50 employees
Work style
Onsite
Industry
Biotechnology
Sub-industry
AI drug discovery / antibody design
13 jobs at Nabla Bio
Offices
Business model
Stage
Series A
Total raised
$37.5M
Latest round
Series A · May 2024
Latest amount
$26M
May 2024 · Radical Ventures
Dec 2021 · Khosla Ventures and Zetta Venture Partners
Mar 2021 · National Science Foundation
Sep 2020
Aug 2020 · Fifty Years
May 2020
Leadership
Co-founder & CEO
Co-founder & President
Chief Business Officer
Co-founder
Data-driven, speed-oriented, rigor-focused, and highly collaborative; the company emphasizes in-person lab work, steep growth, and debating ideas with data rather than ego.
Work style
Onsite
Compensation
Not publicly disclosed; the careers page lists compensation as an FAQ but does not provide a public answer.
Pricing
Primarily partnership-based and licensing-based; pricing terms are not publicly disclosed.
Differentiators
Technology
Customers
Competitors
Estimated revenue
$1M-$10M
Endpoints News · Nov 2025
Described JAM-2 as a major step up in drug-like de novo antibody design, with better success rates, developability, and GPCR results.
Reuters · Oct 2025
Reported a second multi-year Takeda collaboration, with double-digit-million upfront/research payments and potential success-based payments above $1B.
Science · May 2025
Covered Nabla's GPCR-targeting antibody candidates and its test-time scaling approach, including evidence of functional antibody activators.
Endpoints News · Nov 2024
Reported Nabla's progress toward fully computationally designed antibodies and highlighted the company's GPCR-focused de novo antibody work.
Business Wire · May 2024
Announced a $26M Series A led by Radical Ventures and strategic collaborations with AstraZeneca, Bristol Myers Squibb, and Takeda worth more than $550M in upfront and milestone payments plus royalties.