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Matrubials

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Matrubials

Developing milk-inspired therapeutics for infectious diseases

matrubials.com
HQ: Davis, CA, USA
1-10
Healthcare

Company research

Public company, workplace, funding, and market signals

Overview

Matrubials is a Davis, California–based, UC Davis spin-off drug-discovery company developing milk-inspired antimicrobial therapeutics for infectious diseases, with an initial focus on bacterial vaginosis and other women’s health / skin-health applications.

Primary product

Milk-inspired antimicrobial peptide therapeutics for bacterial vaginosis and infectious diseases

Founded

2018

Headquarters

Davis, California, United States

Team size

1-10

Industry

Biotechnology Research

Sub-industry

Anti-infectives / therapeutics drug discovery

Offices

Davis, California, United States

Business model

drug discovery
therapeutics development
grant-funded R&D

Funding

Stage

seed-stage / early-stage

Latest round

Grant (SEGA Health & Life Science Pitch Showcase / Accelerate CA) · Dec 2025

Latest amount

$50K

People & investors

Leadership

Ishita M. Shah

Co-founder and Chief Executive Officer

David A. Mills

Co-founder

J. Bruce German

Co-founder; Professor / Director, Foods For Health Institute

Carlito B. Lebrilla

Co-founder; Distinguished Professor

Investors

Bill & Melinda Gates Foundation
FourthWave Accelerator
Gaingels
Globivest
National Institutes of Health
Pitch Elk Grove
Sacramento Growth Factory
State of California / Accelerate CA
Sunstone Management
The Growth Factory
Y Combinator

Work & culture

Public materials describe an early-stage, collaborative, entrepreneurial team and emphasize inclusion, diversity, and equity; no formal benefits package is publicly listed.

Product & market

Differentiators

  • —Milk-inspired human / mammalian peptide therapeutics
  • —AI-enabled discovery and validation platform
  • —Selective activity aimed at sparing beneficial vaginal lactobacilli
  • —Initial focus on topical BV treatment
  • —UC Davis spin-off with deep academic founder expertise

Technology

AI-enabled candidate expansion and validation platform
milk-derived peptide discovery
antimicrobial peptide therapeutics
in vitro infection assays
mass spectrometry-based bioactive molecule discovery

Customers

women of reproductive age with bacterial vaginosis
patients with drug-resistant bacterial infections
future users of topical skin-health therapeutics

Competitors

Spero Therapeutics
BioNTech
Evofem

Scale & contact

Estimated revenue

about $0.5M annually (third-party estimate)

Estimated monthly visits

598

ishita.shah@matrubials.com

Latest news

Selective Human-Milk-Inspired Antimicrobial Peptides for the Treatment of Bacterial Vaginosis

MDPI Pharmaceutics · Mar 2026

Peer-reviewed publication reporting preclinical results for human-milk-inspired antimicrobial peptides against BV-associated pathogens, including selectivity and safety findings that support Matrubials’ lead program.

Matrubials Wins $50,000 SEGA Health & Life Science Pitch Showcase at Aggie Square

MedStart · Dec 2025

Reports Matrubials won a $50,000 non-dilutive grant via the State of California’s Accelerate CA program and summarizes the company’s BV-focused milk-inspired therapeutic approach.

Davis-based Matrubials to launch skin care product on parallel track with drug candidate

San Francisco Biotechnology Network · Dec 2025

Reports Matrubials plans a consumer skin-care launch alongside its drug candidate, showing a dual-track commercial strategy.

Startup of the Month: Matrubials

Comstock’s magazine

Profiles the company’s UC Davis spin-out origins, funding history, and antibacterial-peptide strategy for bacterial vaginosis.

CareersContact UsFoundersGrantsHomepageIshita M. Shah LinkedInLinkedIn companyMDPI publicationUpdatesWomen’s Health
SourcesMatrubials homepageMatrubials founders pageMatrubials careers pageMatrubials contact pageMatrubials women’s health pageMatrubials grants pageMatrubials NIH SBIR grant postMatrubials LinkedIn company pageIshita M. Shah LinkedInDavid A. Mills LinkedInBruce German LinkedInCarlito Lebrilla LinkedInY Combinator company pageWhiteford Research BiobaseTracxn company profileComstock’s startup profileMedStart SEGA pitch articleMDPI Pharmaceutics articlePubMed recordProspeo revenue estimate

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