BrightCoding · Jun 2026
Coverage of Ligo’s open-source AlphaFold3 implementation, custom GPU kernels, and early-stage research release.
Company research
Public company, workplace, funding, and market signals
Updated Jul 29, 2026
Overview
San Francisco-based YC S24 biotech startup building AI tooling for programmable enzyme design. Ligo combines generative models, experimental feedback, and open-source biomolecular tooling to design novel enzymes and improve chemical manufacturing.
Primary product
AI-powered enzyme design models and programmable enzyme design tooling
Founded
2024
Headquarters
San Francisco, California, United States (HQ listed at 580 California Street, 12th & 16th Floors)
Team size
1-10
Industry
Biotechnology Research
Sub-industry
AI-driven enzyme design / computational biology
Offices
580 California Street, 12th & 16th Floors, San Francisco, CA 94104, United States
Business model
B2B biotechnology platform
custom enzyme design and research partnerships
licensing / enterprise collaborations
Funding
Stage
Pre-seed
Total raised
$500K
Latest round
Pre-Seed · Sep 2024
Latest amount
$500K
Sep 2024 · Y Combinator
People & investors
Leadership
CEO & Co-Founder
CSO & Founder
CTO & Co-Founder
Work & culture
Research-heavy and multidisciplinary, with a small team spanning biology, chemistry, mathematics, and computer science. Public materials emphasize open science, fast experimental feedback, and weekly enzyme-design iteration.
Compensation
No public salary bands found. Public hiring signals include flexible start dates and a $5,000 warm-intro bonus for a hire mentioned in LinkedIn posts.
Product & market
Pricing
Not publicly disclosed; likely B2B partnerships / custom enzyme design engagements
Differentiators
- —Designs enzymes from scratch with generative AI and diffusion models
- —Uses transition-state models plus fast experimental feedback
- —Pairs modeling with wet-lab experimentation
- —Open-sources major biomolecular tooling, including an AlphaFold3 implementation
- —Partnerships with Basecamp Research and Adaptyv Bio
Technology
Python
Jupyter Notebook
Makefile
Shell
PyTorch
PyTorch Lightning
Triton
OpenFold
ProteinFlow
FlashAttention2
FlexAttention
Deepspeed4Science
Customers
Pharmaceutical companies
Agricultural chemical companies
Consumer goods manufacturers (fragrances, food & drink, detergents)
Small chemical companies
Competitors
Xyme
Allozymes
Novozymes
BRAIN Biotech
Anodyne Chemistries
Scale & contact
Estimated revenue
$440k-$513k estimated annual revenue
Estimated monthly visits
1.6K
Latest news
Ligo Biosciences Blog · Jun 2026
Technical research note on optimizer scaling rules and geometric meaning in popular Muon implementations.
Ligo Biosciences Blog · May 2026
Technical research note from Arda Goreci on fold redundancy and why scaling natural sequences may not add as much structural diversity as expected.
Fondo · Feb 2026
Launch coverage describing Ligo’s generative enzyme design approach, target markets, and partnerships with Basecamp Research and Adaptyv Bio.
Sustainable Times · May 2025
Profiles Ligo’s enzyme-design mission, the founders’ Oxford/Y Combinator path, and the company’s open-science breakout around AlphaFold3.
Jobs and careers at Ligo Biosciences
0 jobs at Ligo Biosciences
No open positions
Check back later for new openings