Harmonic Discovery (Medium) · Aug 2024
Company blog post discussing data challenges and the case for explainable, data-rich AI in drug discovery; written by Anna Cichońska and Rayees Rahman.
Multi-targeted therapeutics to treat complex diseases
Company research
Public company, workplace, funding, and market signals
Overview
Harmonic Discovery is a New York-based precision pharmacology biotech using machine learning, structural bioinformatics, and generative chemistry to design multi-target kinase therapeutics and partner on drug discovery and licensing programs.
Primary product
An experimentally validated precision pharmacology platform for kinase drug discovery, including its generative chemistry and selectivity tools (Banyan, Kanopy, Terra) and lead preclinical program HD-10019.
Founded
2021
Headquarters
JLABS@NYC, New York City, New York, United States
Team size
1-10
Work style
Remote
Industry
Biotechnology Research
Sub-industry
Precision pharmacology / kinase drug discovery
Offices
JLABS@NYC, New York City, New York, United States
Business model
proprietary therapeutics development
drug discovery platform
biotech/pharma collaboration and licensing
Funding
Stage
seed
Total raised
$8.1M
Latest round
Incubator/Accelerator - IV · Sep 2025
People & investors
Leadership
Founder & Chief Executive Officer
Founder & Chief Scientific Officer
Director of Data Science and Head of European Operations
Director of Chemical Informatics
Founders
Jason Lee
Co-founder & COO
Work & culture
Interdisciplinary, science-driven, and collaborative; the company describes its team as passionate innovators, radical thinkers, and collaborative builders, with a remote-first US work setup and regular company off-sites.
Work style
Remote
Compensation
Publicly advertised compensation is competitive salary plus equity, a 401(k) match up to 4%, and a five-week PTO package with a holiday bonus; no public salary bands were found.
Benefits
competitive salary
equity compensation
401(k) with up to 4% match
medical insurance
dental insurance
vision insurance
five weeks PTO
holiday bonus equal to 50% of PTO value
quarterly company off-sites
quarterly excursions
Product & market
Pricing
Custom collaboration/licensing agreements; no public pricing published.
Differentiators
- —machine learning-first precision pharmacology platform
- —focus on tuning out toxic off-targets and tuning in beneficial secondary targets
- —multi-target kinase drug discovery rather than single-target design
- —proprietary multimodal data integration across sequence, structure, and expression
- —experimentally validated platform with named internal tools (Banyan, Kanopy, Terra)
- —strong emphasis on kinome-wide selectivity and anti-target avoidance
Technology
machine learning
deep learning
structural bioinformatics
generative chemistry
graph neural networks
multimodal data
Direct Preference Optimization
AlphaFold2-predicted structures
protein-ligand 3D modeling
kinome-wide selectivity prediction
chemogenomics
bioactivity prediction
proprietary data
Customers
biotechnology companies
pharmaceutical companies
academic drug-discovery collaborators
Competitors
Jazz Pharmaceuticals
Sana Biotechnology
C4 Therapeutics
Turbine
Scale & contact
Estimated revenue
under $1M
Estimated monthly visits
825
Latest news
Business Wire · Apr 2024
Harmonic Discovery announced a collaboration with Turbine to co-develop a novel cancer therapy using simulation-guided biology and its multi-target kinase chemistry platform.
PR Newswire · Jan 2024
Harmonic Discovery announced an exclusive licensing agreement for HD-10019, a novel small-molecule candidate for FLT3-mutated AML, and said preclinical development was underway.
Harmonic Discovery (Medium) · Sep 2022
Company launch post announcing $8 million seed funding led by Innovation Endeavors with participation from Fifty Years, Y Combinator, Boom Capital, Caffeinated Capital, and select angel investors.
Harmonic Discovery (Medium) · Sep 2022
Founding post describing the mission to embed disease complexity into drug discovery and build a machine-learning-first platform for kinase therapeutics.
Jobs and careers at Harmonic Discovery
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