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Delfi Diagnostics

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Delfi Diagnostics

delfidiagnostics.com
HQ: Palo Alto, California, United States
200
Healthcare

Company research

Public company, workplace, funding, and market signals

Updated Aug 16, 2026

Overview

DELFI Diagnostics is a privately held cancer-diagnostics company developing blood-based tests that use AI, machine learning, whole-genome sequencing, and cell-free DNA fragmentomics to improve cancer detection and treatment monitoring. Its stated mission is to make early cancer detection more accessible, including for underserved populations.

Primary product

FirstLook Lung™: a laboratory-developed blood test intended to help identify individuals at elevated risk of lung cancer and guide follow-up with guideline-recommended low-dose CT. DELFI also offers DELFI-TF, a research-use-only tumor-fraction assay for treatment monitoring.

Founded

2019

Headquarters

1810 Embarcadero Road, Palo Alto, California 94303, United States

Team size

51-200

Industry

Medical and Diagnostic Laboratories

Sub-industry

Liquid biopsy, cancer diagnostics, clinical laboratory testing, and precision oncology

Offices

Palo Alto, California, United States
Baltimore, Maryland, United States

Business model

B2B healthcare and health-system partnerships
Laboratory-developed testing
Research-use-only testing and pharmaceutical/biotech collaborations
Potential reimbursed clinical diagnostics

Funding

Stage

Late-stage private / commercializing diagnostics company

Total raised

$364.8M

Latest round

Rule 506(b) private financing · Dec 2025

Latest amount

$34.3M

Rule 506(b) private financing

Dec 2025

$34.3M

Strategic equity investment / venture round

Jun 2024 · Merck Global Health Innovation Fund

Series B

Jul 2022

$225M

Series A

Jan 2021 · OrbiMed

$100M

Seed

Aug 2019 · Menlo Ventures

$5.5M

Corporate / initial financing

Jan 2019

People & investors

Leadership

Susan Tousi

Chief Executive Officer

Victor Velculescu

Founder and Board Member; former CEO

Robert Scharpf

Co-Founder and Head of Data Science / Senior Strategy Advisor

Peter Bach

Chief Medical Officer

Amoolya Singh

Chief Technology Officer

Cindy Soriano

Chief Financial Officer

Sarah L. Moseley

Vice President, Medical Affairs

Lorenzo Rinaldi

Head of Translational Science

Marissa Li

Senior Medical Director

Ally Dashner

Chief People Officer

Lee-Ann Smith-Freeman

Vice President of Legal / General Counsel

Charles Newton

Board Member

Investors

Johns Hopkins University / Johns Hopkins Technology Ventures
Menlo Ventures
Merck Global Health Innovation Fund
OrbiMed

Work & culture

Public company materials emphasize scientific rigor, accessibility, health equity, cross-functional collaboration, and translating academic research into scalable clinical products. The company has publicly highlighted underserved populations and partnerships with health systems. A third-party employer-data profile reports an overall rating of approximately 4.2/5 from 27 reviews, with culture rated approximately 4.6/5; this is directional rather than an official company statement.

Compensation

Public compensation data is limited. No reliable DELFI-specific salary bands or equity terms were identified. Third-party employer data reports compensation satisfaction of approximately 4.3/5, but this should not be treated as verified compensation benchmarking.

Product & market

Pricing

Not publicly disclosed. FirstLook Lung is offered through health-system and laboratory channels; the company is pursuing reimbursement and has not published a standard self-pay price in the reviewed sources.

Differentiators

  • —Fragmentomics analyzes genome-wide patterns in cfDNA rather than relying only on a narrow mutation or methylation panel.
  • —FirstLook Lung can be integrated with routine blood work and is designed to help overcome low adherence to low-dose CT screening.
  • —The platform is applicable across cancer detection, cancer subtyping, immunotherapy response prediction, and treatment monitoring.
  • —The company reports a 99.8% negative predictive value for FirstLook Lung in cited validation materials.
  • —DELFI has health-system partnerships and EMR-integration efforts aimed at improving access in underserved populations.
  • —The company reports CLIA certification, CAP accreditation, ISO 13485 certification, and ISO 27001 certification.

Technology

AI and machine learning
Whole-genome sequencing
Cell-free DNA (cfDNA) analysis
DNA fragmentomics
Machine-learning classifiers
Python
TensorFlow
PyTorch
MLflow
Databricks
Kubernetes
SQL
Jupyter
NVIDIA
AWS/RDS-related infrastructure
Git and GitHub
Java
MLOps
Next-generation sequencing

Customers

OSF HealthCare
City of Hope
Allegheny Health Network
Lahey Hospital & Medical Center
Hackensack Meridian Health
Immunocore
Biotech and pharmaceutical companies using DELFI-TF in clinical research

Competitors

GRAIL
Exact Sciences
Freenome
Guardant Health
Natera
Foundation Medicine / Roche
Tempus AI
Caris Life Sciences
NeoGenomics
Quest Diagnostics

Scale & contact

Estimated revenue

Approximately $1M-$10M annually; one third-party company profile estimates $7.6M

Estimated monthly visits

4.8K

Traffic estimate as of Jun 2026

Signals & risks

Other
May 2026

FirstLook Lung remains a laboratory-developed test and has not been cleared or approved by the FDA. DELFI received New York State authorization to offer the test, but FDA in-vitro diagnostic approval remains a separate and material regulatory milestone.

Source
Other
Jan 2026

The company is seeking broader payer reimbursement and expects future clinical, guideline, and regulatory milestones to be important to commercial adoption. Pricing and reimbursement terms remain largely undisclosed.

Source
Other

Third-party employee data indicates approximately 98 employees and a year-over-year decline of about 10.7%. This is a workforce trend signal, not evidence of a confirmed layoff event.

Source

Latest news

DELFI Diagnostics Receives New York State Clinical Laboratory Permit, Completing Authorization to Serve Health Systems Across All 50 States

DELFI Diagnostics / PR Newswire · May 2026

DELFI announced New York State authorization for FirstLook Lung, making the laboratory-developed test available in all 50 states while it continues pursuing FDA approval.

DELFI Diagnostics Gives 'First Look' at Clinical Utility of cfDNA Assay in Lung Cancer Screening

GenomeWeb · May 2026

GenomeWeb reported FIRSTLUNG results showing approximately 80% sensitivity, 56% specificity, and a 99.8% negative predictive value; access to the assay increased overall screening roughly threefold and low-dose CT screening approximately 1.5-fold.

DELFI Diagnostics to Present First Clinical Utility Data at ATS 2026

DELFI Diagnostics / PR Newswire · May 2026

The company announced five ATS 2026 presentations covering clinical utility, real-world implementation, health equity, and at-home blood collection for lung cancer screening.

DELFI Diagnostics Appoints Cindy Soriano as Chief Financial Officer

DELFI Diagnostics / PR Newswire · Jan 2026

Cindy Soriano was promoted to CFO after serving as VP of Finance and Investor Relations; the company highlighted upcoming clinical and regulatory milestones.

DELFI Diagnostics Announces Equity Investment from Merck Global Health Innovation Fund

DELFI Diagnostics / PR Newswire · Jun 2024

Merck's corporate venture arm made an undisclosed equity investment to accelerate DELFI's AI-enabled fragmentomics platform and cancer-detection commercialization.

Clinical research / publications via newsroomCompany homepageFirstLook Lung product siteLinkedIn company pageSEC EDGAR company filings
SourcesDELFI Diagnostics homepage and company profileDELFI Diagnostics newsroomSEC Form D, December 2025 financingSEC Form D, 2022 Series B financingJohns Hopkins Ventures company historyDELFI announcement: Susan Tousi appointed CEODELFI announcement: Merck Global Health Innovation Fund investmentDELFI announcement: FirstLook Lung clinical utility dataGenomeWeb: FIRSTLUNG clinical utility resultsDELFI announcement: New York State authorization

Jobs and careers at Delfi Diagnostics

9 jobs at Delfi Diagnostics

Clinical Data Manager / Senior Clinical Data Manager (Contract)

Remote
Software Engineering & IT
Remote
2d ago
Remote
Contract
Apply

Senior Scientist, Assay Development

On-site
Assay Research & Development
Palo Alto, CA
2d ago
On-site
Full-time
Apply

Manager Equipment Service Engineering

On-site
Lab Operations
Palo Alto, CA
1w ago
On-site
Full-time
Apply

Accounting Operations Manager

Hybrid
Finance
Palo Alto, CA
1w ago
Hybrid
Full-time
Apply

Sr. Data Scientist, Assay Development

Hybrid
Data Science
Palo Alto, CA
3w ago
Hybrid
Full-time
Apply

Director / Senior Director, Market Access & Reimbursement

Remote
Market Access
Remote
4w ago
Remote
Full-time
Apply

Senior Clinical Laboratory Associate (Contract)

On-site
Lab Operations
Palo Alto, CA
1mo ago
On-site
Contract
Apply

Automation Engineer I/II (Contract)

On-site
Assay Research & Development
Palo Alto, CA
2mo ago
On-site
Contract
Apply

Senior Director, Clinical Development

Hybrid
Clinical Development
Palo Alto, CA
3mo ago
Hybrid
Full-time
Apply

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