Origin Bio blog · Mar 2026
Releases 10,000 AI-designed proximal enhancer-like sequences across three cell types with predicted activity, TF-binding annotations, quality metrics, and 3D structures on Switch.
Public company, workplace, funding, and market signals
Updated Jul 29, 2026
Origin Bio is a San Francisco biotech startup founded in 2025 and backed by Y Combinator Winter 2026. It builds a tissue-first cancer biology platform that maps patient tumors with spatial, molecular, and functional readouts, and trains multimodal AI models (including Axis) to improve target discovery, perturbation-response prediction, and safer cell/gene therapy design.
Primary product
A tissue-first cancer biology platform plus the Axis multimodal AI model for regulatory DNA design and prediction.
Founded
2025
Headquarters
San Francisco, California, United States
Team size
1-10
Industry
Biotechnology Research
Sub-industry
Computational biology / drug discovery
Offices
0 jobs at Origin
Check back later for new openings
Business model
Stage
Y Combinator-backed pre-seed
Latest round
Y Combinator Winter 2026 · Feb 2026
Feb 2026 · Y Combinator
Investors
Research-heavy and open-science oriented: the team publishes technical blog posts, releases public sequence datasets, and emphasizes wet-lab plus model-building work. Publicly, it is hiring engineers and researchers and seeking pharma/biotech partnerships.
Pricing
Not publicly disclosed; appears partnership- and licensing-led, with some research access offered via a free API.
Differentiators
Technology
Customers
Competitors
Origin Bio blog · Mar 2026
Releases 10,000 AI-designed proximal enhancer-like sequences across three cell types with predicted activity, TF-binding annotations, quality metrics, and 3D structures on Switch.
Origin Bio blog · Mar 2026
Benchmarks MuonW against AdamH for regulatory-DNA modeling and reports ~37% fewer FLOPs to reach target validation perplexity, while discussing optimizer behavior on DNA tasks.
Y Combinator · Feb 2026
YC launch post describing Origin's cell/gene therapy safety focus, proprietary regulatory-DNA dataset, and partnerships with pharma and biotech companies.
Origin Bio blog · Oct 2025
Announces Axis, a multifunctional AI model that generates regulatory DNA elements and predicts their function; the post claims improved regulatory-element prediction versus AlphaGenome and describes the model/data architecture.