Jobs with Startups
JobsStartupsInvestorsMCP
JobsFreenome

Senior Staff Software Engineer

Freenome logo

Freenome

Healthcare

Senior Staff Software Engineer

Remote
Remote
Full-time
$188k – $270k
Posted Nov 3, 2026
Apply on company site

Opens the original job posting

Engineering
Remote

About this opportunity:

At Freenome, we are seeking a Senior Staff Software Engineer to grow our Platform team. Join a stellar group of engineers who serve our mission to save lives with early cancer detection as we develop and commercialize new blood test products. In this role, you’ll bring compute platform expertise to shape technical direction and mentor others, while staying hands-on and close to design, code, and operations.
Platform Engineering's goal at Freenome is to multiply the productivity of domain experts. We build shared cloud services spanning a governed data lakehouse, batch and distributed compute, and self-service environments for research and analytics, championing developer effectiveness beyond engineering. We combine white-glove support with dedicated partnerships, bringing expert consulting and hands-on engineering to help specialist teams solve complex technical problems and meet critical business milestones.

This role reports to our Director of Engineering, Platform. This is a remote position within the US, with occasional travel to our headquarters in Brisbane, CA, 2-3 times a year.

What you’ll do:

  • Shape Platform’s technical vision and roadmap, working with engineering and R&D leaders to align platform priorities with company goals.
  • Treat Platform and Data as Products, building trust with leads and SMEs from domain teams, and translating shared needs into reusable platform solutions.
  • Design and ship scalable platform systems, evolving the architecture through reviews, rapid prototypes, and pragmatic technology choices.
  • Drive business-critical initiatives, resolving tradeoffs, sequencing work into incremental deliverables and delegating to scale execution.
  • Support platform users to unblock critical work, troubleshoot complex system issues, and turn recurring issues into lasting reliability and capacity improvements.
  • Champion AI adoption across Freenome, pairing with domain experts and tailoring guidance and tools to varied technical backgrounds.
  • Expand our team’s impact by using AI for platform enhancements, and by building platforms for AI that empower Freenome users to create and deploy secure, cost-effective agentic workflows and LLM-powered applications.
  • Increase visibility of cloud costs, recommend and drive initiatives to reduce waste while protecting performance, reliability, and scientific productivity.
  • Grow other engineers through pairing, design review, delegation and feedback, while modeling Freenome’s values and reinforcing a high-performing culture.

Must haves:

  • 12+ years of relevant software engineering experience or equivalent, preferably in platform teams, delivering complex systems from design to production.
  • 3+ years guiding complex initiatives end-to-end across teams: aligning stakeholders, communicating tradeoffs clearly, and enabling delivery without formal authority.
  • 3+ years building and operating production platforms using Infrastructure as Code on a public cloud, preferably Azure or GCP.
  • Proficiency in Python and at least one other high-level programming language.
  • Deep knowledge of Linux internals, networking and virtualization, with hands-on troubleshooting and performance tuning at system level.
  • Solid Kubernetes expertise, with experience owning one or more advanced capabilities such as controllers, operators and CRDs, admission control, scheduling, autoscaling, service mesh, or multi-cluster networking.
  • Sound judgment in distributed systems and platform design, including governance, capacity, reliability, cost, data processing and storage.
  • Software architecture leadership: you ship clean code, write clear design docs and ADRs, and guide constructive reviews and collaborative technical decisions. 
  • You are a force multiplier who enjoys helping engineers or domain experts grow, with a track record of making teams more capable and independent.
  • Success partnering with one or more specialist teams - such as data science, AI/ML, computational biology or related fields - to improve their workflows.
  • Hands-on AI-assisted development and a record of building reusable tools or workflow automation.

Nice to haves:

Experience, familiarity or a genuine interest in some of the following are preferred:

  • Life-sciences software, NGS pipelines and biological data
  • ML Ops, model development and deep learning
  • Scientific Python frameworks and data-science technology stack
  • Workflow orchestration and distributed compute frameworks on Kubernetes
  • Cloud migrations, multi-cloud or multi-region operations
  • Columnar processing, open lakehouse technologies, and modern table formats such as Apache Iceberg
  • FinOps practices, workload cost attribution, and measurable cloud savings

Benefits and additional information:

The US target range of our base salary for new hires is $188,275 - $270,375. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered.  Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ freenome.com/job-openings/ for additional company information.  

Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

Applicants have rights under Federal Employment Laws.  

  • Family & Medical Leave Act (FMLA)
  • Equal Employment Opportunity (EEO)
  • Employee Polygraph Protection Act (EPPA)

California applicants please review the CCPA Notice at Collection here:

  • California Consumer Privacy Act (CCPA)

#LI-Remote

Apply for this role
Freenome logo

Freenome

Company profile

AI-driven blood test for early cancer detection.

View Freenome

Headquarters

San Francisco, CA, USA

Keep exploring

More roles at Freenome

View all roles

Computational Biologist I

Computational Science · Remote

Senior Manager, Total Rewards

People · Brisbane, California; Hybrid

Senior Systems Integration Engineer

Development · Brisbane, California; Hybrid

Senior Software Engineer, Site Reliability

Engineering · Remote

Postmarket Quality Manager

Quality (R&D) · Brisbane, California; Brisbane, California, United States

Jobs with Startups © 2026

Browse startupsBrowse jobsMCP guideAboutPowered by Supabase