Handshake is the career network for the AI economy. 20 million knowledge workers, 1,600 educational institutions, 1 million employers (including 100% of the Fortune 50), and every foundational AI lab trust Handshake to power career discovery, hiring, and upskilling, from freelance AI training gigs to first internships to full-time careers and beyond. This unique value is leading to unparalleled growth; in 2025, we tripled our ARR at scale.
Why join Handshake now:
Shape how every career evolves in the AI economy, at global scale, with impact your friends, family and peers can see and feel
Work hand-in-hand with world-class AI labs, Fortune 500 partners and the world’s top educational institutions
Join a team with leadership from Scale AI, Meta, xAI, Notion, Coinbase, and Palantir, among others
Build a massive, fast-growing business with billions in revenue
About the Role
As a Senior Applied AI Engineer at Handshake AI Enterprise, you'll embed directly inside enterprise customer environments as part of a small, expert team. You'll learn each customer's business deeply, their workflows, their bottlenecks, where the real leverage is, and translate that understanding into production-grade AI agents that measurably change how they operate.
This isn't an implementation or consulting role. You'll own the full stack: defining the solution, building and deploying agents, designing evals, and iterating until performance actually moves. Over time, you'll become a genuine domain expert in your customer's vertical and use that expertise to build AI that keeps getting better.
If you've built AI that works in the real world and want to do it again at much higher stakes, with better data, closer lab relationships, and a founding team that moves fast, this is the role.
What You'll Do
Embed directly with enterprise customers as part of a small deployment team, developing deep understanding of their business and workflows
Define AI-driven solutions based on real business needs, not theoretical use cases
Build and deploy production-grade agents tailored to specific customer use cases, owning end-to-end delivery
Design and run evals to measure agent performance; iterate and hill-climb until results move
Become a domain expert in your customer's vertical and use that expertise to build better AI over time
Work closely with Product and Platform engineers on your team to ship cohesive, reliable solutions
Establish engineering best practices, agent patterns, and reusable frameworks that help the team scale output without sacrificing quality
Surface insights from deployments that inform Handshake's platform and product roadmap
What We're Looking For
5-6+ years of engineering experience, with strong applied AI and backend depth
Real-world experience building and shipping AI applications in production, not just fine-tuning or prototyping
Strong understanding of agent architectures, evals, and how to measure and systematically improve AI performance
Comfort working directly with enterprise customers in ambiguous, high-stakes environments
Strong systems thinking, you can zoom out to the business problem and zoom in to the technical solution without losing either thread
High ownership mentality, you care about outcomes, not just outputs
Strong communication skills, you'll be in the room with senior stakeholders regularly and need to earn their trust quickly
Location: San Francisco, CA | 5 days/week in-office
Extra Credit
Background at a company with a forward deployment or field engineering model
Experience building multi-agent systems in production
Domain expertise in a specific enterprise vertical (recruiting, finance, ops, legal, etc.)
Familiarity with enterprise security requirements, VPC deployments, or on-prem configurations
History of building evals infrastructure or AI quality measurement tooling
Handshake delivers benefits that help you feel supported—and thrive at work and in life.
The below benefits are for full-time US employees.
🎯 Ownership: Equity in a fast-growing company
💰 Financial Wellness: 401(k) match, competitive compensation, financial coaching
🍼 Family Support: Paid parental leave, fertility benefits, parental coaching
💝 Wellbeing: Medical, dental, and vision, mental health support, $500 wellness stipend
📚 Growth: $2,000 learning stipend, ongoing development
💻 Remote & Office: Internet, commuting, and free lunch/gym in our SF office
🏝 Time Off: Flexible PTO, 15 holidays + 2 flex days
🤝 Connection: Team outings & referral bonuses
Explore our mission, values, and comprehensive US benefits at joinhandshake.com/careers.